PHARMACOLOGICAL AND BIOCHEMICAL CHANGES IN ANIMALS MADE AGGRESSIVE BY ISOLATION.
Abstract
The decrease of brain serotonin turnover in aggressive animals was confirmed and was found to be proportional to the different conditions of graded isolation experimentally adopted. Other biochemical parameters, as represented by brain noradrenaline turnover and N-acetyl-L-aspartic acid levels, are changed by prolonged isolation. More precisely in aggressive mice brain noradrenaline turnover is increased whereas the levels of N-acetyl-L-aspartic acid are decreased: no evident changes can be found for what is concerning the cholineacetylase activity in brain between normal and aggressive mice. Chlordiazepoxide showed the interesting property of preventing the behavioral effect of isolation, when administered chronically to the animals. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1968
- Accession Number
- AD0674665
Entities
People
- E. Giacalone
- L. Valzelli
- S. Consolo
- S. Garattini
Organizations
- Mario Negri Institute for Pharmacological Research