INVESTIGATIONS IN THE FIELD OF DIBASIC CARBOXYLIC ACIDS (ISSLEDOVANIYA V OBLASTI DVUOSNOVNYKH KARBONOVYKH KISLOT),
Abstract
The curare-like activity of the aminoesters of succinic acid and a number of its derivatives stimulated the synthesis of new structural analogs of the widely known muscular relaxant, dithilin. In this report the homologous series of dialkylaminoethyl esters of alkylthiosuccinic acids are described. These compounds were synthesized from the acid anhydrides by their reaction with the sodium alcoholate of the amino alcohol and later with dialkylaminoethyl chloride in absolute toluene. With the exception of the methyl and butylthiohomologs the synthesized aminoesters and anhydrides of the alkylthisuccinic acids are described for the first time. The pharmacological study of the quaternary salts of the aminoesters indicated that the introduction of the alkylthio group into the acid portion of the dithilin molecule significantly reduces the curare action of dithilin. The most active are the diiodomethylates of dimethylaminoethyl esters of propyl- and amylthiosuccinic acids which do not cause changes in respiration and blood pressure during complete curarization with minimally active doses 0.25-0.5 and 0.1-0.25 mg/kg correspondingly. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 04, 1967
- Accession Number
- AD0674686
Entities
People
- A. A. Gamburyan
- A. L. Midzhoyan
- G. A. Mednikyan
- N. A. Babiyan
- Zh. A. Shakaryan
Organizations
- National Air and Space Intelligence Center