ON THE EXISTENCE OF TWO TYPES OF ANTIBODIES TO DNA
Abstract
This report states that in the sera of patients with systemic lupus erythematosus, it is possible that at least 2 types of antibodies to DNA are present: Antibodies interacting only with single-stranded molecules of DNA, and antibodies combining with both native and single-stranded preparations of DNA. Antibodies of the first type are encountered sufficiently often in healthy persons and various experimental animals. Their quantity increases during certain illnesses: Leprosy, tuberculous bronchoadenitis. A considerable increase was observed in the quantity of antibodies to single-stranded DNA during scrofuloderma and during banal lymphadenitis accompanied by suppuration of the lymph node. However, due to an insufficient amount of material a final conclusion cannot be made. The impression is created that one of the reasons for the appearance of antibodies to DNA may be inflammatory processes accompanied by suppuration in the lymphatic apparatus.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1967
- Accession Number
- AD0675098
Entities
People
- A. M. Poverennyi
- M. I. Levi
Organizations
- United States Army Biological Warfare Laboratories