THE POSSIBILITY OF THE EXPERIMENTAL TRANSFORMATION OF VARIOLA MAJOR VIRUS INTO VACCINIA VIRUS

Abstract

The two strains of variola major virus multiplied well during the process of 50 successive passages in cell cultures of human and bovine embryo skin, exerting a cytopathological effect on cells. Changes in the properties of the variola virus did not take place as a result of lengthy cultivation under the stated conditions: Similar to the initial condition, both viral strains remained non-cytopathological for cell cultures of chick embryos and in the chorio-allantois of developing chick embryos and in a HEp-1 cell culture caused morphological changes which were sharply different from those caused by the cowpox and vaccinia viruses.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1966
Accession Number
AD0675100

Entities

People

  • N. T. Saraeva
  • N. V. Yaroslavskaya
  • V. D. Solovev
  • Yu. N. Mastyukova

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Animals
  • Cells
  • Culture Techniques
  • Diseases And Disorders
  • Fibroblasts
  • Giant Cells
  • Infection
  • Lepidoptera
  • Materials
  • Membranes
  • Microbiology
  • Poxviridae Infections
  • Russian Language
  • Skin
  • Virology
  • Viruses
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Virology (or Medical Virology).