EXPERIMENTAL AIRBORNE TULAREMIA

Abstract

A study was made of the histopathological changes and also of the accumulation of microbes in guinea pigs during the process of inspiring F. tularensis in an experimental dynamic chamber for inhalation of an infectious aerosol. After a certain period of time, in the normal guinea pigs the number of microbes reached high indices, particularly in the lungs, lymph nodes, spleen and liver. In guinea pigs, actively immunized subcutaneously with Fracisella (500,000 microbial cells) and subjected to treatment with an infectious aerosol containing F. tularensis No. 2713 in a quantity of 1 and 100 D1m, the proliferation bore a different nature - the infectious agent penetrated only the regional lymph nodes.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1968
Accession Number
AD0675106

Entities

People

  • F. Kintera
  • Vl. Vortel

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Temperature
  • Animals
  • Blood
  • Cells
  • Gammaproteobacteria
  • Infection
  • Lung
  • Lymph Nodes
  • Lymphatic System
  • Macrophages
  • Microorganisms
  • Pressure Gages
  • Rodents
  • Russian Language
  • Tickborne Diseases
  • Tissues
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Aerosol Science/Aerosol Physics
  • Immunology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech