NEIGHBORING GROUP EFFECTS IN PHOSPHONATE ESTER HYDROLYSIS II. SYNTHESIS, HYDROLYSIS, AND TOXICITY DATA ON SUBSTITUTED-PHENACYL P-NITROPHENYL METHYLPHOSPHONATES.
Abstract
The synthesis of p-nitrophenyl phenacyl methylphosphonate, p-methoxyphenacyl p-nitrophenyl methylphosphonate, p-chlorophenacyl p-nitrophenyl methyl-phosphonate, and p-nitrophenacyl p-nitrophenyl methylphosphonate are described. The facile alkaline hydrolysis of these phosphonate esters containing a neighboring ketonic group fit a linear free energy relationship. Toxicity studies suggest that the compounds be handled with due caution. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1968
- Accession Number
- AD0675407
Entities
People
- Arthur Bash
- Claire N. Lieske
- George M. Steinberg
- Joseph W. Hovance
- Peter Blumbergs