AGE AT X-IRRADIATION AND ACUTE RADIATION MORTALITY IN THE ADULT MALE RAT,
Abstract
Male rats received whole body single doses of 250 kvp X-rays at various ages ranging from young adulthood to old age. From probit analysis, the LD50/30 values for groups exposed at 3 or 7 months of age were 851 and 900 R, respectively. After adjustment for the natural morality rate, LD50/30 values for groups exposed at 17, 21, or 24 months of age were 776, 806, and 747 R, respectively. The mean survival time at the LD50/30 for the group exposed at 3 months of age exceeded those for groups irradiated at older ages. The slope of the dose versus survival curve for the youngest group was almost twice that for groups exposed at older ages, reflecting increasing variability of the population with increasing age. These findings indicate that age at exposure is an important variable to be considered in establishing parameters of acute radiation mortality in adult animals. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 05, 1968
- Accession Number
- AD0675514
Entities
People
- Dave C. Jones
- Donald J. Kimeldorf
- Garold K. Osborn
Organizations
- Naval Radiological Defense Laboratory