BLOCKING OF PRODUCTION AND ACTIVITY OF INTERFERON BY AN INHIBITOR INDUCED BY VACCINIA VIRUS

Abstract

When monolayer cultures of chicken fibroblasts are infected with a used strain of vaccinia virus, the production of an inhibitor blocking the formation and effect of interferon is stimulated. The blocking effect of the inhibitor becomes apparent when it is introduced not later than six hours after infecting the culture with interferonogen, which testifies to its effect on the early stages of the formation process of interferon.

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Document Details

Document Type
Technical Report
Publication Date
Oct 16, 1967
Accession Number
AD0675732

Entities

People

  • A. E. Gummenik
  • T. A. Bektemirov

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Animal Diseases
  • Arbovirus Infections
  • Cells
  • Fibroblasts
  • Hydrochloric Acid
  • Inhibition
  • Inhibitors
  • Interferon
  • Intervals
  • Materials
  • Mouth Diseases
  • Poxviridae Infections
  • Production
  • Proteins
  • Tissue Culture
  • Viruses

Readers

  • Infectious Disease/Epidemiology
  • Molecular Biology and Genetics