MECHANISM OF ACTION OF BOTULINAL TOXIN ON RESPIRATION
Abstract
Botulinal toxin causes (in animals) respiratory disorders, which, at first, manifest themselves by the increased respiratory frequency and by depression of respiration, later by a decreased frequency and by a decline in the amplitude of respiratory movements, particularly in a protraction of the exhalation action. Subsequently, a recurrent respiration ensues and the paralysis of the respiratory center follows. As a result of administered botulinal toxin, changes in the reflex reaction of respiration affect the stimuli of the vagus nerve and, to some extent, those of the sciatic nerve, which is reflected in the excitability of the respiratory center during botulinal intoxication. Directly after administration of the toxin one observes an increased excitability in the respiratory centers. But, some time later following administration of the toxin, a decline in the threshold value of the respiratory center's excitability changes to an increase. Then, one can observe parabiotic phase phenomena in the respiratory center. The excitability of the phrenic nerve changes slightly during botulinal intoxication. The disorders in respiratory movements of animals during botulinal intoxication are combined with a development of the parabiotic condition in the respiratory center.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1966
- Accession Number
- AD0675832
Entities
People
- V. N. Abrosimov
Organizations
- United States Army Biological Warfare Laboratories