EFFECT OF BOTULINE TOXIN B ON TISSUE RESPIRATION IN THE BRAIN OF GUINEA PIGS

Abstract

Botuline toxin in a dose of 1 Dlm and 100 Dlm affects the respiration of tissues in myelencephalon more than in cerebral hemispheres. The administration of 1 Dlm of botuline toxin caused intensification of respiratory processes 20 minutes later in examined tissues; they were manifested by a predominantly increased liberation of carbon dioxide and by advanced respiratory quotient. Dose of toxin increased to 100 Dlm induced a decline in the level of respiratory processes in cerebral hemispheres. The reaction in myelencephalon brought alongside with a decrease in oxygen absorption also an intensified liberation of carbon dioxide.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1966
Accession Number
AD0675840

Entities

People

  • Z. P. Pak

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Absorption
  • Animals
  • Botulism
  • Brain
  • Carbon Dioxide
  • Central Nervous System
  • Diseases And Disorders
  • Hemispheres
  • Keto Acids
  • Maryland
  • Nervous System
  • Peripheral Nervous System
  • Respiration
  • Rodents

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Microbial Pathology