OBSERVATIONS ON THE MECHANISM OF THE SENSITIZING ACTION OF BOTULINAL TOXIN

Abstract

In studying the inhibition of the phagocytic properties of leukocytes under the influence of botulinal toxin administered to the organism it was discovered that the inhibition of the phagocytosis to a maximal degree is also observed in leukocytes after one day. The coinciding time periods which involve the maximal sensitivity of animals to the microbe after its sensitization by the toxin, together with the maximal simultaneous drop in the animals' phagocytic capacity, lead to the conclusion that the botulinal toxin's 'sensitization' mechanism has its effect on the microbic causative agent.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1966
Accession Number
AD0675843

Entities

People

  • K. I. Chervyakova
  • S. M. Minervin
  • S. P. Zhak

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Animals
  • Blood
  • Botulism
  • Central Nervous System
  • Connective Tissue
  • Dilution
  • Hematologic Tests
  • Infection
  • Inhibition
  • Lethal Dosage
  • Leukocytes
  • Microbiology
  • Microorganisms
  • Nervous System
  • Observation
  • Rodents
  • Volume

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Immunology
  • Mathematics or Statistics