STUDY OF THE IMMUNOLOGICAL EFFECTIVENESS OF COMPLEX IMMUNIZATION AGAINST GAS GANGRENE, TETANUS AND BOTULISM IN EXPERIMENTS ON MONKEYS,
Abstract
The significance of the quality of the primary immunization with associated preparations was demonstrated in experiments on monkeys. Perfringens toxoid, not well purified and not sorbed, introduced in inadequate doses (10 to 20 BU per 1 ml) into the complex tritoxoid and pentatoxoid preparations proved to possess but weak immunizing properties even in triple immunization with a subsequent revaccination. A remote revaccination, conducted 9 months after the primary one, or 2 years after the first revaccination, proved to be more effective with respect to the perfringens and oedematiens antitoxin titer. A revaccination, carried out after 9 years following the primary immunization, proved to be almost ineffective with respect to the perfringens component. A remote revaccination, conducted after 9 years following the immunization, proved to be very effective with respect to titers of botulinal antitoxin of the A and B types. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1966
- Accession Number
- AD0675873
Entities
People
- I. A. Larina
- S. A. Zelevinskaya
- T. I. Bulatova
Organizations
- United States Army Biological Warfare Laboratories