EFFECT OF DRUGS ON OCULAR COUNTERROLLING,
Abstract
To determine the temporal effect of each of several selected drugs and a placebo upon ocular counterrolling, a specific indicator of otolith activity, measurements under controlled conditions were made before and at various times after the oral administration of the drug or placebo. A pool of nine normal subjects participated, and from four to six were used in each experimental trial. Alcohol, 1 cc/lb body weight, had a marked and progressive depressant effect on the amount of eye roll during the intoxication period; complete recovery was recorded six hours after its ingestion. Scopolamine, meclizine, acetylsalicylic acid, meprobamate, chlordiazepoxide hydrochloride, d-amphetamine, and diphenidol, given in twice the usually recommended doses, had little or no effect. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 05, 1968
- Accession Number
- AD0675956
Entities
People
- Ashton Graybiel
- Earl F. Miller Ii.
Organizations
- Naval Aerospace Medical Institute