MECHANISM OF THE EFFECT OF INTERFERON ON THE MULTIPLICATION OF VACCINIA VIRUS AND CELL METABOLISM

Abstract

Interferon suppressed multiplication of the vaccinia virus in a chick fibroblast tissue culture. Treatment of chick fibroblast cells with interferon before their infection with vaccinia virus suppressed the synthesis of virus DNA and, to a lesser extent, that of virus protein. Interferon altered cell metabolism, suppressing the incorporation of adenine-C14 in all the fractions studied, and particularly in the protein fraction. In the cells infected with vaccinia virus but not treated with interferon an increase in isotope capture was noted in the DNA fraction after three hours, and in all the fractions studied after 24 hours.

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Document Details

Document Type
Technical Report
Publication Date
Oct 24, 1967
Accession Number
AD0677835

Entities

People

  • I. A. Kozlova
  • L. A. Melnikova
  • O. P. Peterson
  • T. I. Balezina

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acids
  • Cells
  • Fibroblasts
  • Infection
  • Inoculation
  • Interferon
  • Membranes
  • Metabolism
  • Nucleic Acids
  • Poxviridae Infections
  • Protein Metabolism
  • Proteins
  • Tissue Culture
  • Tissue Culture Cells
  • Tissues
  • Viruses
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Analytical Chemistry
  • Virology (or Medical Virology).