THE EFFECT OF BACTERIAL TOXINS ON TISSUE CULTURE

Abstract

Bacterial toxins (excepting tetanic) caused various degrees of degenerative changes in the cells of a tissue culture of human embryos. The dynamics and characteristics of these changes seemed to be heterogeneous, when the effects of exotoxins and endotoxins were compared. Specific and selective effects of bacterial toxins on the cells of various kinds of tissue culture were noted. With the combined action of exotoxins on a culture of human embryo fibroblasts, the cytotoxic effect was intensified, and pathologic changes in the cells occurred before those taking place in the control cells. The combined effect of endotoxins of dysenteric (Flexner) and abdominal-typhous microbes did not intensify degeneration of the tissue culture of human embryo fibroblasts.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 21, 1967
Accession Number
AD0677836

Entities

People

  • G. E. Arkadeva

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Bacteria
  • Bacterial Toxins
  • Biological Toxins
  • Cells
  • Cytoplasm
  • Diseases And Disorders
  • Endotoxins
  • Experimental Data
  • Fibroblasts
  • Infectious Diseases
  • Literature
  • Microorganisms
  • Tissue Culture
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Microbial Pathology
  • Molecular and Cellular Biology
  • Theoretical Analysis.