INVESTIGATION OF THE POSSIBILITY OF ORAL IMMUNIZATION OF EXPERIMENTAL ANIMALS WITH THE SMALLPOX VACCINE VIRUS. REPORT I. IMMUNOLOGICAL CHANGES IN THE VACCINATED ANIMALS

Abstract

A live smallpox virus administered perorally to experimental animals (monkeys, rabbits and guinea pigs) induced immunological changes (a rise in the antihemagglutinin titers and virus-neutralizing antibodies). Simultaneously, there was an increase of cutaneous immunity, determined by intracutaneous inoculation of rabbits with the smallpox vaccine, as per Grott.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Nov 20, 1967
Accession Number
AD0678119

Entities

People

  • A. A. Vorobeyev
  • A. D. Ukraintsev
  • G. T. Patrikeyev
  • V. M. Enichev

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Animals
  • Gastrointestinal Tract
  • Immunity
  • Immunization
  • Intestines
  • Laboratory Animals
  • Lagomorphs
  • Lepidoptera
  • Medical Personnel
  • Poxviridae Infections
  • Rodents
  • Small Intestine
  • Tissue Culture
  • Vaccines
  • Viruses

Fields of Study

  • Biology

Readers

  • Immunology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology