MECHANISM OF THE PASTEUR EFFECT

Abstract

When nucleated pigeon erythrocytes are treated with nitrite or hydrogen peroxide the Pasteur effect is lost or greatly diminished: the respiration remains unchanged, but aerobic lactic acid formation sets in, attaining the level of anaerobic glycolysis. The effect does not depend on methemoglobin formation: in nitrited cells incubation with excess lactate brings about a complete reduction of methemoglobin, but the inhibition of the Pasteur effect persists. The suppression of the Pasteur effect produced by H2O2 was found to be reversible and disappears on subsequent treatment with sodium hydrosulphite, though this has no effect on nitrited cells.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1963
Accession Number
AD0678143

Entities

People

  • V. S. Shapot

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Biochemistry
  • Cells
  • Chemistry
  • Erythrocytes
  • Glycolysis
  • Inhibition
  • Lactic Acid
  • Malonates
  • Materials
  • Methemoglobin
  • Oxygen
  • Partial Pressure
  • Respiration
  • Respiratory System
  • Rocket Oxidizers
  • Substrates
  • Sugars

Fields of Study

  • Biology

Readers

  • Electrochemical Engineering/ Fuel Cell Technologies
  • Immunology
  • Mathematics or Statistics