A STUDY OF THE INTENSITY OF CROSS AND TYPE IMMUNITY IN BRUCELLOSIS

Abstract

Investigations which were made with guinea pigs to test the intensity of type and cross immunity produced by live vaccines of the type Br. abortus (No 104-M, No 19-BA) and melitensis (Elberg's strain Rev. 1) with respect to infection by highly virulent cultures of Br. melitensis (No 565), Br. suis (No 1330), and Br. abortus (10L) do not provide a basis for indicating that cross immunity is weaker than type immunity in the case of brucellosis. In a comparative study of the immunogenicity of vaccine strains of the cattle and sheep types under conditions of testing the intensity of immunity by various doses of highly virulent cultures of Br. melitensis, suis and abortus, it was established that strain Rev 1 has a high immunogenicity which is not inferior to that of Br. abortus No 104-M. Strain Br. abortus No 104-M upon subcutaneous vaccination produced immunity in guinea pigs to cultures of Br. abortus, suis, and melitensis which were more intense than was the case with strain Br. abortus No 19-BA.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1968
Accession Number
AD0678905

Entities

People

  • D. S. Kurdina
  • P. A. Vershilova

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Bone Marrow
  • Brucellosis
  • Coefficients
  • Hydrogen Sulfides
  • Immunity
  • Infection
  • Intensity
  • Laboratory Animals
  • Lymphatic System
  • Resistance
  • Rodents
  • Russian Language
  • Vaccination
  • Vaccines
  • Virulence
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology

Technology Areas

  • Biotechnology