RETARDED IMMUNOLOGICAL RECOVERY IN SUBLETHALLY X-IRRADIATED MICE BY ADDITIONAL THYMIC EXPOSURE. REVERSAL WITH INJECTED MARROW CELLS,
Abstract
The role of the intact thymus in recovery of the immune response following a sublethal dose of X radiation was studied. Groups of adult LAF1 mice were exposed to 500 rad of X rays and some of these animals, appropriately lead-shielded, then received an additional 500, 1000, or 2000 rad to the thymic area through a 1.2 cm diameter shield opening. Three criteria of immunological response were employed: (1) numbers of Jerne antibody plaque-forming cells (PFC) in the spleen; (2) concentration of antigen-reactive cells (ARC); (3) rejection time of skin homografts. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 24, 1968
- Accession Number
- AD0679675
Entities
People
- Leonard J. Cole
- William E. Davis Jr.
Organizations
- Naval Radiological Defense Laboratory