A GENUS SPECIFIC COMPLEMENT FIXATION ANTIGEN FROM NEISSERIA MENINGITIDIS

Abstract

A simple method for preparing an N. meningitidis complement fixing antigen is described. Hyperimmune rabbit N. meningitidis antiserum reacted approximately the same with CF antigens made from several N. meningitidis groups or strains. Recruits known to have become infected with N. meningitidis strain Bo during recruit training show equal serological responses to CF antigens made from 5 different N. meningitidis groups or strains. Further, 4 recruits who were admitted to the hospital with clinical meningitis also seroconverted equally to any 1 of 6 different N. meningitidis CF antigens. Increase in CF titer (4-fold or greater) to N. meningitidis correlated significantly with acquisition of meningococcus in the nasopharynx as determined by bacterial isolations.

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Document Details

Document Type
Technical Report
Publication Date
Apr 29, 1968
Accession Number
AD0679753

Entities

People

  • Elizabeth A. Edwards
  • L. F. Devine

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Antibodies
  • Biomedical Research
  • Cellular Structures
  • Diseases And Disorders
  • Great Lakes
  • Health
  • Health Services
  • Hospitals
  • Immune Serums
  • Infection
  • Lakes
  • Materials
  • Meningitis
  • Navy
  • Public Health
  • Training

Fields of Study

  • Biology

Readers

  • Immunology
  • Infectious Disease/Epidemiology