VIRULENCE AND ANTIGENICITY OF A STRAIN OF BACILLUS ANTHRACIS CULTIVATED AT 45 DEGREES. II
Abstract
On cultivation of B. anthracis at 45C the virulence was reduced to the level of virulence of vaccine strains. A broth culture of B. anthracis cultivated at 45C lay as regards virulence between the first and second of Tsenkovsky's vaccines and possessed high immunizing properties (after a single injection rabbits acquired a high degree of immunity). On prolonged passage of a 7 day culture on to artificial nutrient media, and also repeated passage in mice, the newly acquired properties were not changed. Therefore this method of attenuation can be used for the purpose of preparing an anthrax vaccine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1958
- Accession Number
- AD0680345
Entities
People
- I. F. Batyuk
Organizations
- United States Army Biological Warfare Laboratories