RADIOPROTECTION WITH 2-(1 DECYLAMINO) ETHANETHIOSULFURIC ACID IN THE RHESUS MONKEY

Abstract

An attempt was made to provide radioprotection of the Macaca mulatta primates by the use of 2-(1 decylamino) ethanethiosulfuric acid, a long chain, lipid-soluble compound. The animals were divided into seven groups: two drug control groups, one radiation control group, and four treatment groups. Each treatment group received a different dosage of drug or had a different latent period between administration of the drug and total-body irradiation. Clinical parameters were monitored and one animal from three of the treatment groups as well as two drug controls were necropsied and examined for signs of radiation damage or drug toxicity. Survival times were compared between treated animals and controls. Results indicate that this compound, given as described, does not afford the predicted degree of radioprotection.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1968
Accession Number
AD0680844

Entities

People

  • George S. Melville Jr.
  • Robert M. Paull

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aerospace Medicine
  • Analysis Of Variance
  • Animals
  • Data Science
  • Information Science
  • Ionizing Radiation
  • Medical Personnel
  • Monkeys
  • Primates
  • Radiation
  • Radiation Sickness
  • Rhesus Monkeys
  • Signs And Symptoms
  • Statistical Analysis
  • Statistics
  • Toxicity
  • X Rays

Fields of Study

  • Biology
  • Psychology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Nuclear and Radiation Engineering.