IMMUNOGENESIS IN ANTI-CHOLERA VACCINATION WITH THE USUAL AND WITH SHORTENED INTERVALS BETWEEN INOCULATIONS (PRELIMINARY COMMUNICATION)
Abstract
The intensity of development of agglutinins in animals vaccinated against cholera with different intervals between inoculations was directly proportional to the length of the interval. The bactericidal activity of these sera rose independently of the duration of intervals; it lasted longest and was most constant in the case of rabbits immunized with 5 hr intervals between injections. A direct relationship was revealed between the bactericidal activity and agglutinin titre of the same sera during the first post-vaccination period, and an inverse one towards the end. Therefore agglutinin titre is an inadequate criterion of degree of immunity. On investigating the active immunity of mice with different intervals nearly identical results were obtained, indicating that a sufficient degree of immunity developed on vaccinating animals by any of the methods which we used.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1968
- Accession Number
- AD0681322
Entities
People
- A. S. Khristova
- K. S. Gylybov
Organizations
- United States Army Biological Warfare Laboratories