THE EFFECT OF HIGH CONCENTRATIONS OF CARBON DIOXIDE ON BLOOD SEROTONIN LEVELS IN MAN. CHRONIC HYPERCAPNIA.
Abstract
Whole blood serotonin levels in young men were investigated during exposure to a 4% carbon dioxide environment (PICO2 = 29.9 mm. Hg) for a 10-day period. No significant change in serotonin levels was found in those men acting as outside controls at ambient (0.03%) carbon dioxide, but there was a 34.0% decrease (P < .01) of serotonin levels in men exposed to 4% carbon dioxide. Exposure to 4% carbon dioxide produced throbbing headaches (day 1-2) and nausea (day 4-6). Serotonin levels after an initial depression tended to return to control levels during the 4% carbon dioxide exposure period. Observed correlation between carbon dioxide and serotonin suggests that the role of carbon dioxide in control of cerebral circulation may be mediated through serotonin. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1968
- Accession Number
- AD0681501
Entities
People
- Edward D. Gordon Jr
Organizations
- United States Air Force School of Aerospace Medicine