A COMPREHENSIVE STUDY OF VIRAL HEPATITIS

Abstract

With the assistance of this contract, human viral hepatitis and a great variety of other hepatic diseases known are suspected to be caused by viruses that were investigated. Of these diseases the principal ones were human neonatal giant cell hepatitis, human cytomegalic inclusion disease and rubella as well as mouse hepatitis and mouse cytomegalic inclusion disease. These human and experimental infections were studied by morphologic and biologic methods in the hope that a better understanding of the mechanism of viral liver injury will lead to better control of human viral hepatitis. Particular attention was paid to a study of cell death in the liver by electron microscopy and histochemistry. This led to a comparison of hyaline and lytic necrosis. The possible protective role of the reticuloendothelial system, the harmful effect of cortisone and the role of lysosomes in protecting the cell against some viral infections were also explored.

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Document Details

Document Type
Technical Report
Publication Date
Feb 10, 1969
Accession Number
AD0681871

Entities

People

  • Boris H. Ruebner
  • E. D. Shaw

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Blood
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Congenital Abnormalities
  • Contracts
  • Diseases And Disorders
  • Electron Microscopy
  • Endoplasmic Reticulum
  • Giant Cells
  • Hepatitis
  • Infection
  • Laboratory Animals
  • Liver Diseases
  • Lymphatic System
  • Medical Personnel
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Molecular and Cellular Biochemistry

Technology Areas

  • Microelectronics