DEVELOPMENT OF A MODEL SYSTEM FOR STUDIES OF MALABSORPTION IN DIARRHIC ANIMALS.
Abstract
Studies of water absorption by the small intestine, as this phenomenon relates to certain electrolytes, have been completed. This information shall be utilized in determination of changes in fluid movement across the intestinal epithelium during induced malabsorption and the diarrheic state. In addition, a technique for the isolation of the epithelial cell brush border has been developed, and the preferential binding of bile salts to ileal brush borders has been established. Kinetic models to describe the preference of the ileum as opposed to the jejunum for these substances are being prepared. Similar studies to evaluate the electrolyte requirement of these organelles in the absorptive process are in progress. Our studies should provide important parameters in establishing functional changes in the epithelium during early intestinal pathologies. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 30, 1968
- Accession Number
- AD0682011
Entities
People
- Arthur S. Nunn Jr.
- William A. Summers
Organizations
- Indiana University Bloomington