STRESS RESPONSE AS A PREDICTOR OF RADIOSENSITIVITY IN PRIMATES,

Abstract

Macaca mulatta primates were standardized and then subjected to stress in the form of prolonged breathing of an air atmosphere saturated with ethanol vapor. Significant changes (P < .01) were noted in their urine volumes and the excretion of electrolytes and 17-hydroxycorticoids. The primates were then irradiated with a lethal dose (1,100 R) of gamma radiation. Their survival times were recorded and tested for correlation with body weights, urine volumes, excretion of electrolytes and corticoids, and post-stress blood alcohol levels. The changes in the Na/K urinary ratio were found to be significantly (P < .01) related to the respective postirradiation survival times, but no significant correlation between survival time and the other measurements was detected. (Author)

Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1968
Accession Number
AD0682285

Entities

People

  • George S. Melville Jr.
  • Horace E. Hamilton

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

DTIC Thesaurus Topics

  • Atmospheres
  • Body Weight
  • Electrolytes
  • Excretion
  • Gamma Rays
  • Lethal Dosage
  • Measurement
  • Radiation
  • Respiration
  • Survival

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Electrochemical Engineering/ Fuel Cell Technologies
  • Nuclear and Radiation Engineering.