STUDIES OF BOTULINUM ANTIGENS AND ANTISERA BY ZONE ELECTROPHORESIS AND AGAR GEL DIFFUSION

Abstract

Studies show that the production of type A botulinum toxins in cellophane sacs is practicable, economical and of great practical importance. The method of fractionation by paper electrophoresis, preparative electrophoresis, immuno-electrophoresis and precipitation by diffusion in agar applied to a study of the fractions and antigenic structure of toxins, toxoids and antitoxins, and also to establish the role of each separate fraction, will be of assistance in establishing the requirements which preparations of the highest quality should comply with, and in devising the most rational method for the purification and concentration of antigens and antibodies.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1958
Accession Number
AD0682630

Entities

People

  • Yu. Z. Gendon

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Antitoxins
  • Bacteria
  • Bacterial Toxins
  • Cellophane
  • Clinical Laboratory Techniques (Medicine)
  • Death
  • Diffusion
  • Electrophoresis
  • Fractionation
  • Globulins
  • Immune Serums
  • Paper
  • Precipitation
  • Proteins
  • Rodents
  • Toxins And Antitoxins

Fields of Study

  • Biology

Readers

  • Immunology
  • Molecular and Cellular Biochemistry
  • Systems Analysis and Design