REMOTE REACTIONS OF HEMATOPOIETIC TISSUE TO PROTON AND X-RAY IRRADIATION IN COMBINATION WITH G-FORCES,
Abstract
The remote reactions of hematopoietic tissue to the combined effects of x-rays or protons and acceleration (G-forces) were studied in mice of both sexes, exposed to six different combinations of irradiation and centrifugation as shown in the table. Some of the animals died within two months; the balance were kept under observation for 2 years. Mice displaying hematopoietic disturbances were killed for morphohistological study. Karyological studies (Ford's and Fox's methods) were made of bone marrow and spleen cells of 14 mice showing symptoms of leukosis and leukemia at various time intervals after exposure. The results show that protons, like x-rays, are a leukemogenic (blastomogenic) factor. Mice are very sensitive to G-forces; many died shortly after exposure, while the survivors displayed increased susceptibility to infectious disease. These effects were especially pronounced when G-forces were combined with x-rays, and less severe when G-forces were combined with protons. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 29, 1968
- Accession Number
- AD0682794
Entities
People
- B. I. Davydov
- E. I. Zharova
- S. A. Khrustalev
- T. G. Protasova
- V. V. Antipov
Organizations
- National Air and Space Intelligence Center