PRESERVATION OF HUMAN BLOOD FROM MALE AND FEMALE DONORS.
Abstract
Units of human blood were obtained from male and female donors and compared for changes in pH, ATP levels, in vitro spontaneous hemolysis, hexokinase activity, G-6-PD levels and osmotic resistance during storage in ACD for a period up to 42 days. The data show that, by the criteria of the above determinations, the blood obtained from female donors is better able to survive the storage lesions than the blood from male donors. These results are attributed to the different endocrine systems in the human male and female and the capacity to form structurally and pharmacologically different endogenous steroid hormones. The possibility that these steroid hormones could interact with components of the red cell membrane and limit an increase in cell membrane permeability is discussed. A sample of blood obtained from an 8-month pregnant human female was also studied; the pattern of preservation of such blood was essentially the same as that observed with the blood of female donors. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 12, 1968
- Accession Number
- AD0683501
Entities
People
- Dorothy F. Ligon
- Frankc DeVenuto
- Harold L. Wilson
- Sarah S. Morse
Organizations
- United States Army Medical Research Laboratory