DEMONSTRATION OF BLOOD GROUP SUBSTANCE A BOUND TO PASTEURELLA PESTIS
Abstract
Washed P. pestis bacilli prepared from a vaccine containing peptides and peptones of animal origin elicited human anti-A red cell hemolysins in rabbits, whereas similarly treated P. pestis from a vaccine containing peptones and peptides of plant origin did not. Whole vaccine and its various subfractions did not stimulate antibody production for any of the human red cell types when injected into rabbits. Apparently, human blood group A specifically is imparted to P. pestis by blood group contaminating sources present in the media used to cultivate the organism. The evidence shows that, in rabbits, the specific substance expresses itself antigenically only when a concentrated amount is bound to the cell, and that in soluble form it is weakly antigenic or present in subminimal antigenic concentrations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 05, 1968
- Accession Number
- AD0683502
Entities
People
- Anthony J. Luzzio
Organizations
- United States Army Medical Research Laboratory