CONSTRUCTION OF AN INTERNAL THORACIC DUCT FISTULA.

Abstract

Lymphocyte depletion produces readily apparent immunological defects. The major defect lies in delayed sensitivity response and, if controlled, it can result in a more effective method of immunologic suppression in transplantation. The present study was an attempt to develop a method of establishing chronic internal lymphatic diversion and, thereby, produce lymphopenia without the sequelae of fluid, electrolytic and caloric loss. A modified Absolon thoracic duct fistula was devised and tested in ten dogs. However, the results in the eight technically satisfactory dogs were no better than those of Absolon, and no advantage was observed in renal homotransplantation models. This report describes the technique and examines possible reasons for failure when used by this investigator. (Author)

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1968
Accession Number
AD0684174

Entities

People

  • Gerald Klebanoff

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Construction
  • Hematologic Diseases
  • Hemic And Immune Systems
  • Lymphatic System
  • Lymphocytes
  • Sensitivity
  • Transplantation

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech