POTENTIAL ANTIMALARIALS STRUCTURALLY RELATED TO QUININE.
Abstract
The base-catalyzed condensation of 3-quinuclidinone with quinoline carboxaldehydes provides easy access to a large number of compounds which may be loosely described as desvinylquinine derivatives. Many such substances have been synthesized and submitted for antimalarial screening. Of particular interest are the quinolinemethanols obtained by acid-catalyzed hydration of the condensation products. The unique metal complexes of 2-(2'-quinolyl)methylene-3-quinuclidinone which were encountered during this work and progress on an attempt to synthesize the complete quinine skeleton are also described. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 07, 1969
- Accession Number
- AD0684364
Entities
People
- David L. Coffen
Organizations
- University of Colorado Boulder