INVESTIGATION OF PATHOGENESIS AND TREATMENT OF SHOCK.
Abstract
Septic shock is frequently characterized by a hyperdynamic state in which one finds a patient with a high central venous pressure, high cardiac index, low peripheral resistance, oliguria, lacticacidosis, hypoxia and respiratory alkalosis. Despite the high cardiac output there is an accumulation of lactate indicating tissue hypoxia. There is frequently a narrow arterio-venous oxygen difference and a low oxygen uptake. These findings are quite contrary to what one would expect. In exercise the cardiac output goes up and the peripheral resistance drops but the arterio-venous difference increases and oxygen uptake increases. A cellular defect or peripheral arterio-venous shunting appear to be the major abnormality in this form of shock and the direction in which further research is likely to proceed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1969
- Accession Number
- AD0684950
Entities
People
- Lloyd D. Maclean
Organizations
- Royal Victoria Hospital, Barrie