THE EFFECT OF INTERFERON ON THE INHIBITION OF SYNTHESIS OF PROTEINS IN A CULTURE OF CHICK EMBRYO FIBROBLASTS INOCULATED WITH ARBOR VIRUS
Abstract
In chick embryo fibroblasts infected with the virus of Venezuelan equine encephalitis the rate of protein synthesis fell to 20-25% of the initial level within 3 hr after infection. In cultures treated with high concentrations of interferon a subsequent infection failed to cause a decline of protein synthesis not only 3-4 but also 24 hr after infection. The cytopathic effect either did not appear or else (at an infection density of 500 PFU per cell) developed only to a minor degree. Lower concentrations of interferon (32-100 units per ml) inhibited multiplication of the virus but did not prevent the decline of protein synthesis and the development of the cytopathic effect.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 26, 1969
- Accession Number
- AD0685388
Entities
People
- N. V. Kaverin
Organizations
- United States Army Biological Warfare Laboratories