IMMUNOLOGICAL TOLERANCE TO COXSACKIE B3 VIRUS

Abstract

When mice were inoculated with Coxsackie B3 virus at different periods of pregnancy, intrauterine transmission of infection occurred. As a result of inoculation of large virus doses, newborn mice developed the typical infectious process terminating in death of the animals. Some surviving mice showed congenital anomalies. When females were inoculated with reduced virus doses, newborn mice developed immunological tolerance. The study determined maximum and minimum amounts of virus, required for reproduction of this process.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1969
Accession Number
AD0685408

Entities

People

  • N. R. Gutman
  • V. D. Solovev

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Chemical Properties
  • Immunization
  • Infection
  • Influenza
  • Inoculation
  • Materials
  • Microorganisms
  • Poliomyelitis
  • Pregnancy
  • Production
  • Skeletal Muscle
  • Vaccination
  • Viruses
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Virology (or Medical Virology).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.