STUDIES ON MAMMALIAN AND HUMAN PYRUVATE AND ALPHA-KETOGLUTARATE DEHYDROGENATION COMPLEXES.

Abstract

The aims of the project are to resolve the pig heart pyruvate and alpha-ketoglutarate dehydrogenase complexes into their essential constituent enzymes, to characterize the latter, and to determine the composition and macromolecular structure of these two multienzymes. Attempts will be made to locate these multienzyme units in the mitochondrial membrane by using ferritin-antibody against lipoamide dehydrogenase. Finally, these studies will be extended to the alpha-keto acid dehydrogenase systems of human heart and other organs. (Author)

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1968
Accession Number
AD0685464

Entities

People

  • Masahiko Koike

Organizations

  • Nagasaki University

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Antibodies
  • Biological Sciences
  • Carboxylic Acids
  • Chemical Compounds
  • Dehydrogenation
  • Intracellular Membranes
  • Keto Acids
  • Membranes
  • Organic Compounds
  • Pyruvates

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and Cellular Biochemistry