SELECTION OF RADIATION-RESISTANT ANIMALS.
Abstract
Rodents were exposed at weekly intervals to an ethanol-saturated air ambient. Body weight was monitored before and after each exposure. Sedation and recovery times were observed. After a rest period of several days the animals were irradiated to a dose level at which a 100% mortality was expected. The postirradiation survival of the rodents was correlated (P< .05- .01) in preliminary experiments with preirradiation ethanol-induced body weight changes. The weight change-survival relationship was observed in five different species of rodents. The correlation was found to be present for periods of time up to twenty-one days following stress testing. The test may be applicable to animals exposed to a dose range of several hundred roentgens at the dose level producing a high percentage of mortality. No detectable modification of the postirradiation survival time of the stressed animals was observed. Plots of radiation-induced mortality times were made for the five rodent species. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1969
- Accession Number
- AD0686733
Entities
People
- Edwin R. Ballinger
- George S. Melville Jr.
- Horace E. Hamilton
- Ignatius G. Peters
Organizations
- United States Air Force School of Aerospace Medicine