PLAGUE BACILLUS: SURVIVAL WITHIN HOST PHAGOCYTES

Abstract

Pasteurella pestis within neutrophiles and macrophages removed from the peritoneal cavity of guinea pigs during experimental plague were shown to be viable by direct microscopic observation of the infected phagocytes incubating in suitable bacteriologic media. The time-honored hypothesis that the major determinant of the virulence of the plague bacillus is its ability to resist ingestion by phagocytes must be reevaluated.

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Document Details

Document Type
Technical Report
Publication Date
Nov 14, 1968
Accession Number
AD0687364

Entities

People

  • Michael J. Surgalla
  • Werner A. Janssen

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Animals
  • Anti-Bacterial Agents
  • Bacteria
  • Biological Sciences
  • Cells
  • Cellular Structures
  • Environment
  • Gammaproteobacteria
  • Incubation
  • Infectious Diseases
  • Infusions
  • Laboratory Animals
  • Macrophages
  • Pathogenic Bacteria
  • Phagocytes
  • Rodents
  • Survival

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology