SOME TRENDS IN CONSTRUCTION OF INTESTINAL VACCINES,
Abstract
Two trends in the development of intestinal vaccines are considered: creation of vaccines based on factors of pathogeneticity of the causative agent and creation of live vaccines. The importance of 'residual virulence' is discussed. Significant immunogenic activity has been observed in a number of salmonella and shigella mutants, dependent on a number of limiting growth and propagation factors (quanine, streptomycin, methionine), which are not available in the host organism. Strict doses of a limiting factor is considered to be important in immunization with dependent cultures, for immunogenesis stimulation, and sometimes, for more rapid elimination of the immunizing culture from the organism. A streptomycin-resistant revertant of Salmonella quertneri was obtained, which possessed residual virulence and higher immunogenic properties than the parental streptomycin-dependent culture. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 05, 1969
- Accession Number
- AD0688056
Entities
People
- I. F. Mikhailov
Organizations
- United States Army Foreign Science and Technology Center