A RATIONALE FOR THE PREPARATION OF NONTHROMBOGENIC MATERIALS.
Abstract
It is postulated that negative charges, per se, are insufficient to impart thromboresistance to a polymer surface. Rather, it is hypothesized that a specific steric array of negative charges is required; certain distribution favoring thromboresistance and others either not imparting thromboresistance or, indeed, enhancing the possibility of thrombus formation. The distances between charges required may be a function of whether an intramolecular calcium bridge may be formed. It is proposed that truly neutral surfaces may be more suitable as thromboresistant surfaces. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1969
- Accession Number
- AD0688130
Entities
People
- Fred Leonard
Organizations
- Walter Reed Army Medical Center