A NEW MECHANISM FOR THE CALCIFICATION OF SKELETAL TISSUES.

Abstract

A new mechanism for the calcification of skeletal tissue is proposed in which ATP present in high levels in the mineralizing zone of cartilage first complexes calcium. The calcium complex is subsequently hydrolyzed to calcium acid pyrophosphate and then to hydroxy apatite. During the process, adenosine and orthophosphoric acid are also formed which combine to regenerate ATP. The process is thus cyclical. The mechanism describably by balanced chemical equations is in accord with experimental observations found in the literature and data reported herein. (Author)

Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1969
Accession Number
AD0688131

Entities

People

  • Fred Leonard
  • Roger I. Scullin

Organizations

  • Walter Reed Army Medical Center

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Adenosine
  • Cartilage
  • Equations
  • Literature
  • Observation
  • Tissues

Readers

  • Analytical Chemistry
  • Immunology and Pathology
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