CYANOACRYLATE ADHESIVES IN EYE WOUNDS.
Abstract
Three main sets of experiments are described in this report: (1) tolerance of cyanocacrylate adhesives in rabbit eyes; (2) in vitro tensile strength of corneal stroma-stroma and sclera-silicone rubber adhesive joints; and (3) sealing corneal and choroidal perforations and lacerations with adhesives. The following adhesives were tested: methyl, isobutyl, n-butyl, n-hexyl, n-heptyl, n-octyl, n-decyl, -trifluoroisopropyl 2-cyanoacrylate, and Biobond. Of these, methyl and -trifluoroisopropyl cyanoacrylates are not well tolerated by eye tissues. Biobond sets too slowly, and does not seem useful for the treatment of eye perforations. Any of the other adhesives tested could be employed to seal both corneal and scleral wounds. Isobutyl 2-cyanoacrylate is the best adhesive found so far when tissue tolerance, tensile strength, and ability to seal eye perforations (alone and with silicone rubber patches) are the criteria. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1969
- Accession Number
- AD0690217
Entities
People
- Miguel F. Refojo