INHIBITORY EFFECT OF INTERFERON ON RIBONUCLEIC ACID OF POLIOMYELITIS AND LOUPING ILL VIRUSES

Abstract

Interferon, obtained by means of infection of cells of chick fibroblasts with the virus of Japanese encephalitis, displayed an inhibiting activity in respect to infectious RNA from the viruses of poliomyelitis and louping ill following direct action in vitro. Inactivation of RNA of the louping ill virus was established in tests on the intracerebral infection of mice, and the virus of poliomyelitis - on a culture of chick fibroblasts which were not sensitive to poliomyelitis virus. The capacity of interferon to inactivate infectious viral RNA during direct interaction with it outside of a tissue culture makes it possible to assume that the same mechanism lies at the basis of the protective effect of interferon.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1966
Accession Number
AD0690315

Entities

People

  • N. A. Ivanova
  • R. Y. Polyak

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Acids
  • Buffers (Chemistry)
  • Cells
  • Chemistry
  • Dilution
  • Fibroblasts
  • Fluids
  • Infection
  • Interferon
  • Materials
  • Nucleic Acids
  • Poliomyelitis
  • Proteins
  • Ribonucleic Acids
  • Tissue Culture
  • Viruses
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Virology (or Medical Virology).