MAXIMUM RATE ANALYSIS OF ERYTHROCYTE CARBONIC ANHYDRASE IN HYPERCAPNIC GUINEA PIGS

Abstract

Studies were made of the activity and concentration of erythrocyte carbonic anhydrase in guinea pigs exposed for up to seven days to atmospheres containing 15% CO2. Data are presented which indicate that adaptive processes tend to reduce the activity per mole of enzyme when the enzyme concentration is increased by such processes as hemoconcentration, i.e., during the first 24-48 hours of CO2 exposure, and to increase activity per mole when enzyme concentration is reduced through use or degenerative processes, or after about seven days of exposure. Several general interpretations are proposed for utilization of data from analyses of a nonlinear activity vs enzyme concentration relationship.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 19, 1969
Accession Number
AD0690386

Entities

People

  • Donald V. Tappan

Organizations

  • Naval Submarine Medical Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Atmospheres
  • Biomedical Research
  • Carbon Dioxide
  • Classification
  • Environment
  • Erythrocytes
  • Experimental Data
  • Materials
  • Navy
  • Recording Systems
  • Rodents
  • Security
  • Submarine Bases
  • Submarines

Readers

  • Mathematics or Statistics
  • Molecular and Cellular Biochemistry
  • Neurotoxicology