BIOLOGIC RESPONSE TO POLYURETHANE FOAM. EVALUATION OF POLYMERS AS SURGICAL PROSTHESES.
Abstract
The report covers investigation of toxicity and biologic fate of rigid polyurethane foam and investigation of acrylate-amide terpolymer fabricated into bile duct, aortic, and esophageal prosthesis. C14 tagged rigid polyurethane foam implanted in the rat tibia and followed for 115 weeks indicates that both ring and side chain labelled implants are slowly mobilized from the site of implant with approximately three-fourths of the implant material remaining in situ two years post implant time. Homogenized viscera were studied for activity from 2 to 63 weeks post implant. No malignant tumors were observed in either tibial or subcutaneous tissue implants of rigid polyurethane observed for 1050 days post implant. Long term (36 months) survival following acrylate-amide common bile duct replacement in dogs is reported No chemical evidence of liver disease was observed. Histologically hepatic periductal inflammation was at 14 months post implant. The majority of dogs show slight to moderate pericholangitis and none show evidence of parenchymal disease. Two types of pre-woven Dacron vascular prostheses with different thicknesses of acrylate-amide foam coatings were evaluated. Acrylate-amide foam was studied for carcinogenicity by subcutaneous implants in rats. Some animals were followed as long as 690 days after implant. No malignant tumors associated with the implants were found. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1969
- Accession Number
- AD0690700
Entities
People
- Roger T. Sherman
Organizations
- University of Tennessee