CHELATED TRACE METALS IN WOUND REPAIR.
Abstract
The ability of a variety of metal binding agents to modify the distribution of injected zinc in guinea pigs was studied. After the formation of a standardized bone wound the subsequent deposition of the metal was measured in the healing tissue, the uninjured bone areas and in other organs. The experimental design included treatment with saline and zinc sulfate as controls. The studies established the possibility of controlled removal of zinc from healing tissue and its selective deposition in regenerating areas by choice of the appropriate ligands. Calcium disodium diethylenetriamine pentaacetic acid effectively causes removal of tissue zinc. Contrastingly, 2,3-dimercaptopropane sulfonic acid and cysteiamine-N-acetic acid, as their zinc chelates, are the most effective agents yet identified for selective delivery of zinc to repair tissues. The experimental results, coupled with a demonstrable relative deficiency of zinc in repair tissue during wound healing, point the way to a therapeutic modality for accelerating wound repair. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1969
- Accession Number
- AD0690858
Entities
People
- Martin I. Rubin
- Steven A. Silverman
Organizations
- Georgetown University