A FURTHER SURVEY OF COMPOUNDS FOR RADIATION PROTECTION
Abstract
The report summarizes the results obtained with 617 compounds tested for their radioprotective activity in adult male mice irradiated with a control- demonstrated LD(99+) of 800 R (250 kvp) x-rays. A compound was considered to exhibit radioprotective activity if it (1) permitted any of the treated mice to survive for 30 days after the otherwise lethal whole-body x-irradiation or (2) increased the median survival time of treated animals by 5 days or more beyond the median survival time of the untreated control mice (9 plus or minus 3 days). Of the 617 compounds tested, 245 successfully passed one or both of the stated specifications. Additionally, data are offered to allow comparisons of chemically related groups for structure-activity relationships, and to indicate the types of structures which offer the greatest promise as a source of more effective and less toxic radioprotective agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1969
- Accession Number
- AD0691490
Entities
People
- John Doull
- Vivian Plzak
Organizations
- University of Chicago