CLINICAL-MORPHOLOGICAL AND IMMUNOLOGICAL PARALLELS IN GUINEA PIGS INFECTED WITH VACCINE AND VIRULENT STRAINS OF R. BURNETTI

Abstract

In guinea pigs a vaccine strain of R. burnetti does not cause a clinically expressed illness, but leads to the formation of specific complement- fixing antibodies, the titers of which are considerably lower than during infection with the same dose of a highly virulent strain. No difference was revealed in the degree of expression of morphological changes in the organs of guinea pigs which were infected with virulent and vaccine strains of R. burnetti. The morphological changes described can be characterized as connected with the formation of immunity to the particular causative agent.

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Document Details

Document Type
Technical Report
Publication Date
Aug 14, 1969
Accession Number
AD0692372

Entities

People

  • A. M. Igonin
  • O. S. Gudima

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Ground and Sea Platforms

DTIC Thesaurus Topics

  • Abdomen
  • Animals
  • Blood
  • Blood Cells
  • Cells
  • Cellular Structures
  • Connective Tissue
  • Heart
  • Incubation
  • Infectious Diseases
  • Lymph Nodes
  • Lymphatic System
  • Lymphocytes
  • Rodents
  • Tissues
  • Vaccines
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Game Theory.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology