BIOCHEMICAL STUDIES ON THE TOXIC NATURE OF SNAKE VENOM

Abstract

Studies on the chemical properties of cobrotoxin have established its amino acid composition, and revealed that the toxin has a single peptide chain of 62 amino acids cross-linked by 4 disulfide bonds with amino terminal leucine and carboxyl terminal asparagine. In comparison with the entire sequence of toxin alpha from the venom of Naja nigricollis the similarities obviously must lie in its alike chemical structure. Knowledge of the sequence of cobrotoxin is required in order to understand the location of the essential amino acid residues required for the maintenance of the active conformation of this type. It is the purpose of this experiment to present the sequence of amino acids in cobrotoxin.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1969
Accession Number
AD0692939

Entities

People

  • Chen-chung Yang

Organizations

  • Kaohsiung Medical University

Tags

DTIC Thesaurus Topics

  • Acetic Acid
  • Amino Acids
  • Aromatic Amino Acids
  • Aspartic Acid
  • Chemical Properties
  • Chemistry
  • Chromatography
  • Degradation
  • Essential Amino Acids
  • Glutamic Acid
  • Glutamine
  • Hydrophilic Properties
  • Neurotoxins
  • Plastic Explosives
  • Terminals
  • Threonine
  • Tryptophan

Fields of Study

  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Superconducting Magnet Technology